Chemoenzymatic synthesis of enantiopure hydroxy sulfoxides derived from substituted arenes
| Data(s) |
07/03/2016
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| Resumo |
<p>Enantiopure β-hydroxy sulfoxides and catechol sulfoxides were obtained, by chemoenzymatic synthesis, involving dioxygenase-catalysed benzylic hydroxylation or arene cis-dihydroxylation and cis-diol dehydrogenase-catalysed dehydrogenation. Absolute configurations of chiral hydroxy sulfoxides were determined by X-ray crystallography, ECD spectroscopy and stereochemical correlation. The application of a new range of β-hydroxy sulfoxides as chiral ligands was examined.</p> |
| Identificador |
http://dx.doi.org/10.1039/c5ob02411k http://www.scopus.com/inward/record.url?scp=84959227427&partnerID=8YFLogxK |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/closedAccess |
| Fonte |
Boyd , D R , Sharma , N D , Malone , J F , Ljubez , V , Murphy , D , Shepherd , S D & Allen , C C R 2016 , ' Chemoenzymatic synthesis of enantiopure hydroxy sulfoxides derived from substituted arenes ' Organic and Biomolecular Chemistry , vol 14 , no. 9 , pp. 2651-2664 . DOI: 10.1039/c5ob02411k |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1600/1606 #Physical and Theoretical Chemistry #/dk/atira/pure/subjectarea/asjc/1600/1605 #Organic Chemistry #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry |
| Tipo |
article |
