New insights into the FLPergic complements of parasitic nematodes: Informing deorphanisation approaches
Data(s) |
01/06/2014
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Resumo |
FMRFamide-like peptide (FLP) receptors are appealing as putative anthelmintic targets. To date, 31 flp-encoding genes have been identified in Caenorhabditis elegans and thirteen FLP-activated G-protein coupled receptors (FLP-GPCRs) have been reported. The lack of knowledge on FLPs and FLP-GPCRs in parasites impedes their functional characterisation and chemotherapeutic exploitation. Using homology-based BLAST searches and phylogenetic analyses this study describes the identification of putative flp and flp-GPCR gene homologues in 17 nematode parasites providing the first pan-phylum genome-based overview of the FLPergic complement. These data will facilitate FLP-receptor deorphanisation efforts in the quest for novel control targets for nematode parasites. |
Formato |
application/pdf |
Identificador |
http://dx.doi.org/10.1016/j.euprot.2014.04.002 http://pure.qub.ac.uk/ws/files/18256565/New_insights.pdf http://www.scopus.com/inward/record.url?scp=84902436534&partnerID=8YFLogxK |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
McCoy , C J , Atkinson , L E , Zamanian , M , McVeigh , P , Day , T A , Kimber , M J , Marks , N J , Maule , A G & Mousley , A 2014 , ' New insights into the FLPergic complements of parasitic nematodes: Informing deorphanisation approaches ' EuPA Open Proteomics , vol 3 , pp. 262-272 . DOI: 10.1016/j.euprot.2014.04.002 |
Palavras-Chave | #FLP #FLP-receptor #FMRFamide-like peptide #Nematode #Neuropeptide GPCR #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry |
Tipo |
article |