Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer
Data(s) |
22/07/2008
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Resumo |
<p>A fluorescence in situ hybridisation (FISH) assay has been used to screen for ETV1 gene rearrangements in a cohort of 429 prostate cancers from patients who had been diagnosed by trans-urethral resection of the prostate. The presence of ETV1 gene alterations (found in 23 cases, 5.4%) was correlated with higher Gleason Score (P=0.001), PSA level at diagnosis (P=<0.0001) and clinical stage (P=0.017) but was not linked to poorer survival. We found that the six previously characterised translocation partners of ETV1 only accounted for 34% of ETV1 re-arrangements (eight out of 23) in this series, with fusion to the androgen-repressed gene C15orf21 representing the commonest event (four out of 23). In 5'-RACE experiments on RNA extracted from formalin-fixed tissue we identified the androgen-upregulated gene ACSL3 as a new 5'-translocation partner of ETV1. These studies report a novel fusion partner for ETV1 and highlight the considerable heterogeneity of ETV1 gene rearrangements in human prostate cancer.</p> |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Attard , G , Clark , J , Ambroisine , L , Mills , I G , Fisher , G , Flohr , P , Reid , A , Edwards , S , Kovacs , G , Berney , D , Foster , C , Massie , C E , Fletcher , A , De Bono , J S , Scardino , P , Cuzick , J , Cooper , C S & Transatlantic Prostate Group 2008 , ' Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer ' British Journal of Cancer , vol 99 , no. 2 , pp. 314-20 . DOI: 10.1038/sj.bjc.6604472 |
Palavras-Chave | #Coenzyme A Ligases #Cohort Studies #DNA-Binding Proteins #Gene Fusion #Gene Rearrangement #Genetic Heterogeneity #Humans #In Situ Hybridization, Fluorescence #Male #Paraffin Embedding #Prostatic Neoplasms #Reverse Transcriptase Polymerase Chain Reaction #Transcription Factors #Translocation, Genetic |
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article |