Characterization of NKR+ T-cell subsets in human bone marrow:implications for immunosurveillance of neoplasia
Data(s) |
01/01/2005
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Resumo |
<p>In addition to hematopoietic progenitors, human bone marrow contains mature T/NK lymphocytes. Valpha24Vbeta11 NKT-cells, a subset of NK receptor+ (NKR+) T-cells in humans, are rare in bone marrow, suggesting the presence of other NKR+ T-cells which may contribute to tumor surveillance. NKR+/- T-cells were examined in blood (PB), and bone marrow from donors (DM) and patients with active hematopoietic malignancy (PM), or in remission (PR). T-cells in PR & PM were enriched for CD56+ and CD57+ subsets, compared to DM. All marrow NKR+/- T-cell subsets were more activated than PB. PM and, surprisingly, PR marrow contained more activated cells than DM. CD8+ cells were significantly increased in all patient marrows and there was evidence of the formation of an effector/memory pool in malignant marrow. These data suggest that NKR+ T-cell enrichment in human bone marrow that has been exposed to neoplastic transformation is compatible with a role in localized tumor surveillance/eradication.</p> |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Dean , J , McCarthy , D , Doherty , D G , O'Farrelly , C , Golden-Mason , L & Lawler , M 2005 , ' Characterization of NKR+ T-cell subsets in human bone marrow : implications for immunosurveillance of neoplasia ' Clinical immunology (Orlando, Fla.) , vol 114 , no. 1 , pp. 42-51 . DOI: 10.1016/j.clim.2004.08.017 |
Palavras-Chave | #Biological Markers #Bone Marrow Cells #Flow Cytometry #Hematologic Neoplasms #Humans #Immunologic Memory #Immunologic Surveillance #Killer Cells, Natural #Lymphocyte Activation #T-Lymphocyte Subsets |
Tipo |
article |