Dietary fat and breast cancer mortality: a systematic review and meta-analysis
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18/02/2015
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Resumo |
<p>Background: The influence of dietary fat upon breast cancer mortality remains largely understudied despite extensive investigation into its influence upon breast cancer risk </p><p>Objective: To conduct meta-analyses of studies to clarify the association between dietary fat and breast cancer mortality Design: MEDLINE and EMBASE were searched for relevant articles published up to March 2012. Risk of all-cause or breast cancer specific death was evaluated by combining multivariable adjusted estimates comparing highest versus lowest categories of intake; and per 20 gram increase in intake of total and/or saturated fat (g/day) using random-effects meta-analyses. </p><p>Results: Fifteen prospective cohort studies investigating total fat and/or saturated fat intake (g/day) and breast cancer mortality were included. There was no difference in risk of breast cancer specific death (n = 6; HR = 1.14; 95% CI: 0.86, 1.52; P = 0.34) or all cause death (n = 4; HR = 1.73; 95% CI: 0.82, 3.6; P = 0.15) for women in the highest versus lowest category of total fat intake. Breast cancer specific death (n = 5; HR = 1.63; 95% CI: 1.19, 2.24; p <0.01) was higher for women in the highest versus lowest category of saturated fat intake. </p><p>Conclusions: These meta-analyses have shown that saturated fat intake negatively impacts upon breast cancer survival.</p> |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Brennan , S F , Woodside , J V , Lunny , P M , Cardwell , C R & Cantwell , M M 2015 , ' Dietary fat and breast cancer mortality: a systematic review and meta-analysis ' Critical Reviews in Food Science and Nutrition . DOI: 10.1080/10408398.2012.724481 |
Tipo |
article |