MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts
Data(s) |
01/01/2012
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Resumo |
Macrophage inhibitory cytokine-1 (MIC-1) is a multifunctional cytokine produced in high amounts by placental tissue. Inhibiting trophoblast invasion and suppressing inflammation through inhibition of macrophage activation, MIC-1 is thought to provide pleiotropic functions in the establishment and maintenance of pregnancy. So far, little is known about the decidual cell subsets producing MIC-1 and the effect of this cytokine on dendritic cells (DCs), which are known to play a distinct role in the development of pro-fetal tolerance in pregnancy. |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Segerer , S E , Rieger , L , Kapp , M , Dombrowski , Y , Müller , N , Dietl , J & Kämmerer , U 2012 , ' MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts ' Human reproduction (Oxford, England) , vol 27 , no. 1 , pp. 200-9 . DOI: 10.1093/humrep/der358 |
Palavras-Chave | #Antigens, CD #Antigens, CD86 #Cell Movement #Cell Proliferation #Decidua #Female #Flow Cytometry #Growth Differentiation Factor 15 #Humans #Immunoglobulins #Indoleamine-Pyrrole 2,3,-Dioxygenase #Inflammation #Interleukin-2 Receptor alpha Subunit #Membrane Glycoproteins #Monocytes #Phenotype #Stromal Cells #Transforming Growth Factor beta #Trophoblasts |
Tipo |
article |