Lung Clearance Index Is a Repeatable and Sensitive Indicator of Radiological Changes in Bronchiectasis
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01/03/2014
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Resumo |
<p>RATIONALE: In bronchiectasis there is a need for improved markers of lung function to determine disease severity and response to therapy.</p><p>OBJECTIVES: To assess whether the lung clearance index is a repeatable and more sensitive indicator of computed tomography (CT) scan abnormalities than spirometry in bronchiectasis.</p><p>METHODS: Thirty patients with stable bronchiectasis were recruited and lung clearance index, spirometry, and health-related quality of life measures were assessed on two occasions, 2 weeks apart when stable (study 1). A separate group of 60 patients with stable bronchiectasis was studied on a single visit with the same measurements and a CT scan (study 2).</p><p>MEASUREMENTS AND MAIN RESULTS: In study 1, the intervisit intraclass correlation coefficient for the lung clearance index was 0.94 (95% confidence interval, 0.89 to 0.97; P < 0.001). In study 2, the mean age was 62 (10) years, FEV1 76.5% predicted (18.9), lung clearance index 9.1 (2.0), and total CT score 14.1 (10.2)%. The lung clearance index was abnormal in 53 of 60 patients (88%) and FEV1 was abnormal in 37 of 60 patients (62%). FEV1 negatively correlated with the lung clearance index (r = -0.51, P < 0.0001). Across CT scores, there was a relationship with the lung clearance index, with little evidence of an effect of FEV1. There were no significant associations between the lung clearance index or FEV1 and health-related quality of life.</p><p>CONCLUSIONS: The lung clearance index is repeatable and a more sensitive measure than FEV1 in the detection of abnormalities demonstrated on CT scan. The lung clearance index has the potential to be a useful clinical and research tool in patients with bronchiectasis.</p> |
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Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Rowan , S A , Bradley , J M , Bradbury , I , Lawson , J , Lynch , T , Gustafsson , P , Horsley , A , O'Neill , K , Ennis , M & Elborn , J S 2014 , ' Lung Clearance Index Is a Repeatable and Sensitive Indicator of Radiological Changes in Bronchiectasis ' American Journal of Respiratory and Critical Care Medicine , vol 189 , no. 5 , pp. 586-92 . DOI: 10.1164/rccm.201310-1747OC |
Palavras-Chave | #Adolescent #Adult #Aged #Aged, 80 and over #Breath Tests #Bronchiectasis #Feasibility Studies #Female #Forced Expiratory Volume #Humans #Lung #Male #Middle Aged #Models, Statistical #Quality of Life #Questionnaires #ROC Curve #Regression Analysis #Respiratory Function Tests #Sensitivity and Specificity #Severity of Illness Index #Spirometry #Tomography, X-Ray Computed #Young Adult |
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article |