Distinct poor prognostic subgroups of acute myeloid leukaemia, FLT3-ITD and P-glycoprotein-positive, have contrasting levels of FOXO1
| Data(s) |
08/11/2013
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| Resumo |
Regulation of ABCB1 (P-glycoprotein/Pgp) in AML was investigated. In a historical cohort with Pgp and transcriptional regulator expression profiling data available (n=141), FOXO1 correlated with Pgp protein expression. This was confirmed in an independent cohort (n=204). Down-regulation (siRNA) or hyperactivation (nicotinamide) of FOXO1 led to corresponding changes in Pgp. Low FOXO1 expression correlated with FLT3-ITDs (p |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Seedhouse , C H , Mills , K I , Ahluwalia , S , Grundy , M , Shang , S , Burnett , A K , Russell , N H & Pallis , M 2013 , ' Distinct poor prognostic subgroups of acute myeloid leukaemia, FLT3-ITD and P-glycoprotein-positive, have contrasting levels of FOXO1 ' Leukemia Research . DOI: 10.1016/j.leukres.2013.10.030 |
| Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2700/2730 #Oncology #/dk/atira/pure/subjectarea/asjc/2700/2720 #Hematology #/dk/atira/pure/subjectarea/asjc/1300/1306 #Cancer Research |
| Tipo |
article |
