Genome scan meta-analysis of schizophrenia and bipolar disorder, part II:Schizophrenia
Data(s) |
01/07/2003
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Resumo |
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studies (R(avg)) and then weighted for sample size (N(sqrt)[affected casess]). A permutation test was used to compute the probability of observing, by chance, each bin's average rank (P(AvgRnk)) or of observing it for a bin with the same place (first, second, etc.) in the order of average ranks in each permutation (P(ord)). The GSMA produced significant genomewide evidence for linkage on chromosome 2q (PAvgRnk |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Lewis , C M , Levinson , D F , Wise , L H , DeLisi , L E , Straub , R E , Hovatta , I , Williams , N M , Schwab , S G , Pulver , A E , Faraone , S V , Brzustowicz , L M , Kaufmann , C A , Garver , D L , Gurling , H M D , Lindholm , E , Coon , H , Moises , H W , Byerley , W , Shaw , S H , Mesen , A , Sherrington , R , O'Neill , F A , Walsh , D , Kendler , K S , Ekelund , J , Paunio , T , Lönnqvist , J , Peltonen , L , O'Donovan , M C , Owen , M J , Wildenauer , D B , Maier , W , Nestadt , G , Blouin , J-L , Antonarakis , S E , Mowry , B J , Silverman , J M , Crowe , R R , Cloninger , C R , Tsuang , M T , Malaspina , D , Harkavy-Friedman , J M , Svrakic , D M , Bassett , A S , Holcomb , J , Kalsi , G , McQuillin , A , Brynjolfson , J , Sigmundsson , T , Petursson , H , Jazin , E , Zoëga , T & Helgason , T 2003 , ' Genome scan meta-analysis of schizophrenia and bipolar disorder, part II : Schizophrenia ' The American Journal of Human Genetics , vol 73 , no. 1 , pp. 34-48 . DOI: 10.1086/376549 |
Palavras-Chave | #Bipolar Disorder #Genome, Human #Genotype #Humans #Schizophrenia |
Tipo |
article |