Effects of modified low-density lipoproteins on human retinal pericyte survival
Data(s) |
01/06/2005
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Resumo |
According to a current paradigm cardiovascular diseases can be initiated by exposure of vascular cells to qualitatively modified low-density lipoproteins (LDL). Capillary leakage, an early feature of diabetic retinopathy, results in the exposure of retinal pericytes to modified LDL, including glycated (G-LDL) and heavily oxidized glycated LDL (HOG-LDL). We demonstrate here that modified LDL inhibits the proliferation and survival of cultured human retinal pericytes. Modified LDL also induced DNA fragmentation in bovine retinal pericytes. Overall, HOG-LDL produced a significantly higher extent of cytotoxicity and apoptosis in retinal pericytes. These results indicate that exposure of pericytes to HOG-LDL could be implicated in the development of diabetic retinopathy. |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Song , W , Barth , J L , Lu , K , Yu , Y , Huang , Y , Gittinger , C K , Argraves , W S & Lyons , T J 2005 , ' Effects of modified low-density lipoproteins on human retinal pericyte survival ' Annals of the New York Academy of Sciences , vol 1043 , pp. 390-5 . DOI: 10.1196/annals.1333.045 |
Palavras-Chave | #Apoptosis #Cell Survival #DNA Fragmentation #Humans #Lipoproteins, LDL #Pericytes #Retina |
Tipo |
article |