Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation
| Data(s) |
2011
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| Resumo |
Vascular smooth muscle cell (SMC) proliferation has an indispensable role in the pathogenesis of vascular disease, but the mechanism is not fully elucidated. The epigenetic enzyme histone deacetylase 7 (HDAC7) is involved in endothelial homeostasis and SMC differentiation and could have a role in SMC proliferation. In this study, we sought to examine the effect of 2 HDAC7 isoforms on SMC proliferation and neointima formation. |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Zhou , B , Margariti , A , Zeng , L , Habi , O , Xiao , Q , Martin , D , Wang , G , Hu , Y , Wang , X & Xu , Q 2011 , ' Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation ' Arteriosclerosis Thrombosis and Vascular Biology , vol 31 , no. 11 , pp. 2676-84 . DOI: 10.1161/ATVBAHA.111.230888 |
| Tipo |
article |
