The effect of radiation technique and bladder filling on the acute toxicity of pelvic radiotherapy for localized high risk prostate cancer
Data(s) |
01/11/2012
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Resumo |
Purpose: The goal of this project was to see if using IMRT to deliver elective pelvic nodal irradiation (EPNI) for prostate cancer reduced acute treatment toxicity. <br/><br/>Methods: Two hundred and thirty patients were enrolled into prospective trials delivering EPNI with a concomitant hypofractionated IMRT boost to the prostate. During accrual, the method of EPNI delivery changed as new literature emerged. Three methods were used (1) 4FB, (2) IMRT with 2 cm CTV margins around the pelvic vessels as suggested by Shih et al. (2005) [7] (IMRT-Shih), and (3) IMRT with nodal volumes suggested by the RTOG (IMRT-RTOG). Initially patients were treated with an empty bladder, with the remainder treated with bladder full.<br/> <br/>Results: Patients in the 4FB group had higher rates of grade 2 acute GI toxicities compared to the IMRT-Shih and IMRT-RTOG groups (31.9% vs 20.8% vs 7.2%, p = 0.0009). Patients in the 4FB group had higher rates of grade 3 urinary frequency compared to the two IMRT groups (8.5% vs 0% vs 0%, p = 0.027). However, multivariate analysis suggested the factor that most influenced toxicity was bladder filling followed by IMRT. <br/><br/>Conclusions: Bladder filling appeared to be the dominant factor which predicted for acute toxicity, followed by the use of IMRT. |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Jain , S , Loblaw , D A , Morton , G C , Danjoux , C , Szumacher , E , Chu , W , Chung , H T , Vesprini , D , Sahgal , A , Zhang , L , Deabreu , A & Cheung , P C F 2012 , ' The effect of radiation technique and bladder filling on the acute toxicity of pelvic radiotherapy for localized high risk prostate cancer ' Radiotherapy and Oncology , vol 105 , no. 2 , pp. 193-197 . DOI: 10.1016/j.radonc.2012.09.020 |
Palavras-Chave | #Prostate cancer #IMRT #Acute toxicity #Bladder filling #Pelvic radiotherapy #/dk/atira/pure/subjectarea/asjc/2700/2730 #Oncology #/dk/atira/pure/subjectarea/asjc/2700/2741 #Radiology Nuclear Medicine and imaging #/dk/atira/pure/subjectarea/asjc/2700/2720 #Hematology |
Tipo |
article |