Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation

Autoria(s): Nassini, Romina; Pedretti, Pamela; Moretto, Nadia; Fusi, Camilla; Carnini, Chiara; Facchinetti, Fabrizio; Viscomi, Arturo Roberto; Pisano, Anna Rita; Stokesberry, Susan; Brunmark, Charlott; Svitacheva, Naila; McGarvey, Lorcan; Patacchini, Riccardo; Damholt, Anders B; Geppetti, Pierangelo; Materazzi, Serena
Data(s)

14/08/2012
Resumo

The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism. However the limited clinical evidence for the role of neurogenic inflammation in asthma or chronic obstructive pulmonary disease raises an alternative possibility that airway inflammation is promoted by non-neuronal TRPA1.
Identificador

http://pure.qub.ac.uk/portal/en/publications/transient-receptor-potential-ankyrin-1-channel-localized-to-nonneuronal-airway-cells-promotes-nonneurogenic-inflammation(453b7f4a-2477-4824-84cb-2c6d3a6d3bb6).html

http://dx.doi.org/10.1371/journal.pone.0042454
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Nassini , R , Pedretti , P , Moretto , N , Fusi , C , Carnini , C , Facchinetti , F , Viscomi , A R , Pisano , A R , Stokesberry , S , Brunmark , C , Svitacheva , N , McGarvey , L , Patacchini , R , Damholt , A B , Geppetti , P & Materazzi , S 2012 , ' Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation ' PLoS ONE , vol 7 , no. 8 , e42454 , pp. e42454 . DOI: 10.1371/journal.pone.0042454
Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1100 #Agricultural and Biological Sciences(all) #/dk/atira/pure/subjectarea/asjc/1300 #Biochemistry, Genetics and Molecular Biology(all) #/dk/atira/pure/subjectarea/asjc/2700 #Medicine(all)
Tipo

article
Acesso ao item digital