Endothelial Progenitors as Tools to Study Vascular Disease


Autoria(s): Medina, Reinhold J.; O'Neill, Christina L.; O'Doherty, T. Michelle; Wilson, Sarah E. J.; Stitt, Alan W.
Data(s)

2012

Resumo

Endothelial progenitor cells (EPCs) have great clinical value because they can be used as diagnostic biomarkers and as a cellular therapy for promoting vascular repair of ischaemic tissues. However, EPCs also have an additional research value in vascular disease modelling to interrogate human disease mechanisms. The term EPC is used to describe a diverse variety of cells, and we have identified a specific EPC subtype called outgrowth endothelial cell (OEC) as the best candidate for vascular disease modelling because of its high-proliferative potential and unambiguous endothelial commitment. OECs are isolated from human blood and can be exposed to pathologic conditions (forward approach) or be isolated from patients (reverse approach) in order to study vascular human disease. The use of OECs for modelling vascular disease will contribute greatly to improving our understanding of endothelial pathogenesis, which will potentially lead to the discovery of novel therapeutic strategies for vascular diseases.

Formato

application/pdf

Identificador

http://pure.qub.ac.uk/portal/en/publications/endothelial-progenitors-as-tools-to-study-vascular-disease(bae7758f-c8c2-4133-b85a-0f6c43670bee).html

http://dx.doi.org/10.1155/2012/346735

http://pure.qub.ac.uk/ws/files/2149464/Endothelial_Progenitors_as_Tools_to_Study_Vascular_Disease.pdf

Idioma(s)

eng

Direitos

info:eu-repo/semantics/openAccess

Fonte

Medina , R J , O'Neill , C L , O'Doherty , T M , Wilson , S E J & Stitt , A W 2012 , ' Endothelial Progenitors as Tools to Study Vascular Disease ' Stem Cells International , vol 2012 , 346735 , pp. 1-5 . DOI: 10.1155/2012/346735

Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1300/1307 #Cell Biology #/dk/atira/pure/subjectarea/asjc/1300/1312 #Molecular Biology
Tipo

article