Antibody-targeted nanoparticles for cancer therapy
Data(s) |
01/03/2011
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Resumo |
In recent years, nanoparticulate-mediated drug delivery research has examined a full spectrum of nanoparticles that can be used in diagnostic and therapeutic cancer applications. A key aspect of this technology is in the potential to specifically target the nanoparticles to diseased cells using a range of molecules, in particular antibodies. Antibody-nanoparticle conjugates have the potential to elicit effective targeting and release of therapeutic targets at the disease site, while minimizing off-target side effects caused by dosing of normal tissues. This article provides an overview of various antibody-conjugated nanoparticle strategies, focusing on the rationale of cell-surface receptors targeted and their potential clinical application. |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Fay , F & Scott , C 2011 , ' Antibody-targeted nanoparticles for cancer therapy ' Immunotherapy , vol 3 , no. 3 , pp. 381-394 . DOI: 10.2217/IMT.11.5 |
Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2700/2723 #Immunology and Allergy #/dk/atira/pure/subjectarea/asjc/2700/2730 #Oncology #/dk/atira/pure/subjectarea/asjc/2400/2403 #Immunology |
Tipo |
article |