ZapA, a virulence factor in a rat model of Proteus mirabilis-induced acute and chronic prostatitis.
Data(s) |
01/11/2008
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Resumo |
Our knowledge of pathogenesis has benefited from a better understanding of the roles of specific virulence factors in disease. To determine the role of the virulence factor ZapA, a 54-kDa metalloproteinase of Proteus mirabilis, in prostatitis, rats were infected with either wild-type (WT) P. mirabilis or its isogenic ZapA- mutant KW360. The WT produced both acute and chronic prostatitis showing the typical histological progressions that are the hallmarks of these diseases. Infection with the ZapA- mutant, however, resulted in reduced levels of acute prostatitis, as determined from lower levels of tissue damage, bacterial colonization, and inflammation. Further, the ZapA- mutant failed to establish a chronic infection, in that bacteria were cleared from the prostate, inflammation was resolved, and tissue was seen to be healing. Clearance from the prostate was not the result of a reduced capacity of the ZapA- mutant to form biofilms in vitro. These finding clearly define ZapA as an important virulence factor in both acute and chronic bacterial prostatitis. |
Identificador |
http://dx.doi.org/10.1128/IAI.00122-08 http://www.scopus.com/inward/record.url?scp=55849135540&partnerID=8YFLogxK |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Phan , V , Belas , R , Gilmore , B F & Ceri , H 2008 , ' ZapA, a virulence factor in a rat model of Proteus mirabilis-induced acute and chronic prostatitis. ' Infection and Immunity , vol 76 , no. 11 , pp. 4859-4864 . DOI: 10.1128/IAI.00122-08 |
Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2400/2403 #Immunology #/dk/atira/pure/subjectarea/asjc/2400/2404 #Microbiology #/dk/atira/pure/subjectarea/asjc/2400/2405 #Parasitology #/dk/atira/pure/subjectarea/asjc/2700/2725 #Infectious Diseases |
Tipo |
article |