Interleukin-4 and interleukin-4 soluble receptor α levels in bronchoalveolar lavage from children with asthma
Data(s) |
01/04/2003
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Resumo |
Background: In asthma there is increased expression of the Th2-type cytokine interleukin-4 (IL-4). IL-4 is important in immunoglobulin isotype switching to immunoglobulin E and adhesion of eosinophils to endothelium.<br/><br/>Objectives: We hypothesized that levels of IL-4 in bronchoalveolar lavage (BAL) fluid would be increased in stable, atopic asthmatic children compared with controls and that levels of its physiologic inhibitor IL-4 soluble receptor α (IL-4sRα) would be correspondingly decreased.<br/><br/>Methods: One hundred sixteen children attending a children's hospital for elective surgery were recruited. A nonbronchoscopic BAL was performed, and IL-4 and IL-4sRα were measured in the BAL supernatants.<br/><br/>Results: There was no significant difference in IL-4 concentrations between atopic asthmatic children, atopic normal controls, and nonatopic normal controls [0.13 pg/mL (0.13 to 0.87) vs 0.13 pg/mL (0.13 to 0.41) vs 0.13 pg/mL (0.13 to 0.5), P = 0.65]. IL-4sRα levels were significantly increased in asthmatic patients compared with atopic controls [6.4 pg/mL (5.0 to 25.5) vs 5.0 pg/mL (5.0 to 9.9), P = 0.018], but not when compared with the nonatopic controls [5.2 pg/mL (5.0 to 10.6), P = 0.19].<br/><br/>Conclusions: Contrary to expectation, IL-4sRα levels are increased in BAL from stable asthmatic children compared with nonatopic controls, and we speculate that IL-4sRα is released by inflammatory cells in the airways to limit the proinflammatory effects of IL-4.<br/> |
Identificador |
http://dx.doi.org/10.1016/S1081-1206(10)61828-5 http://www.scopus.com/inward/record.url?scp=0037391870&partnerID=8YFLogxK |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Fitch , P S , Brown , V , Schock , B , Ennis , M & Shields , M 2003 , ' Interleukin-4 and interleukin-4 soluble receptor α levels in bronchoalveolar lavage from children with asthma ' Annals of Allergy, Asthma and Immunology , vol 90 , no. 4 , pp. 429-433 . DOI: 10.1016/S1081-1206(10)61828-5 |
Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2700/2723 #Immunology and Allergy |
Tipo |
article |