(18)F-FDG PET-CT simulation for non-small-cell lung cancer: effect in patients already staged by PET-CT.
Data(s) |
01/05/2010
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Resumo |
Purpose: Positron emission tomography (PET), in addition to computed tomography (CT), has an effect in target volume definition for radical radiotherapy (RT) for non–small-cell lung cancer (NSCLC). In previously PET-CT staged patients with NSCLC, we assessed the effect of using an additional planning PET-CT scan for gross tumor volume (GTV) definition. Methods and Materials: A total of 28 patients with Stage IA-IIIB NSCLC were enrolled. All patients had undergone staging PET-CT to ensure suitability for radical RT. Of the 28 patients, 14 received induction chemotherapy. In place of a RT planning CT scan, patients underwent scanning on a PET-CT scanner. In a virtual planning study, four oncologists independently delineated the GTVon the CT scan alone and then on the PET-CTscan. Intraobserver and interobserver variability were assessed using the concordance index (CI), and the results were compared using the Wilcoxon signed ranks test. Results: PET-CT improved the CI between observers when defining the GTVusing the PET-CT images compared with using CTalone for matched cases (median CI, 0.57 for CTand 0.64 for PET-CT, p = .032). The median of the mean percentage of volume change from GTVCT to GTVFUSED was 5.21% for the induction chemotherapy group and 18.88% for the RT-alone group. Using the Mann-Whitney U test, this was significantly different (p = .001). Conclusion: PET-CT RT planning scan, in addition to a staging PET-CT scan, reduces interobserver variability in GTV definition for NSCLC. The GTV size with PET-CT compared with CT in the RT-alone group increased and was reduced in the induction chemotherapy group. |
Identificador |
http://dx.doi.org/10.1016/j.ijrobp.2009.04.045 http://www.scopus.com/inward/record.url?scp=77950592144&partnerID=8YFLogxK |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Hanna , G , Carson , K , Lynch , T , McAleese , J , Cosgrove , V , Eakin , R , Stewart , D P , O'Sullivan , J & Hounsell , A 2010 , ' (18)F-FDG PET-CT simulation for non-small-cell lung cancer: effect in patients already staged by PET-CT. ' International journal of radiation oncology, biology, physics , vol 77 , no. 1 , pp. 24-30 . DOI: 10.1016/j.ijrobp.2009.04.045 |
Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1306 #Cancer Research #/dk/atira/pure/subjectarea/asjc/2700/2730 #Oncology #/dk/atira/pure/subjectarea/asjc/2700/2741 #Radiology Nuclear Medicine and imaging #/dk/atira/pure/subjectarea/asjc/3100/3108 #Radiation |
Tipo |
article |