Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene

Autoria(s): Maier, L.M.; Twells, R.C.J.; Howson, J.M.M.; Lam, A.C.; Clayton, D.G.; Smyth, D.J.; Savage, David; Carson, Dennis; Patterson, Christopher; Smink, L.J.; Walker, N.M.; Burren, O.S.; Nutland, S.; Rance, H.; Tuomilehto-Wolf, E.; Tuomilehto, L.; Guia, C.; Ionescu-Tirgoviste, C.; Undlien, D.E.; Ronningen, K.S.; Cucca, F.; Todd, J.A.
Data(s)

01/10/2003
Identificador

http://pure.qub.ac.uk/portal/en/publications/testing-the-possible-negative-association-of-type-1-diabetes-and-atopic-disease-by-analysis-of-the-interleukin-4-receptor-gene(9de8e848-2507-4762-9066-0be2f4cd0976).html

http://dx.doi.org/10.1038/sj.gene.6364007

http://www.scopus.com/inward/record.url?scp=3242802855&partnerID=8YFLogxK
Idioma(s)

eng
Direitos

info:eu-repo/semantics/restrictedAccess
Fonte

Maier , L M , Twells , R C J , Howson , J M M , Lam , A C , Clayton , D G , Smyth , D J , Savage , D , Carson , D , Patterson , C , Smink , L J , Walker , N M , Burren , O S , Nutland , S , Rance , H , Tuomilehto-Wolf , E , Tuomilehto , L , Guia , C , Ionescu-Tirgoviste , C , Undlien , D E , Ronningen , K S , Cucca , F & Todd , J A 2003 , ' Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene ' Genes and Immunity , vol 4 , no. 7 , pp. 469-475 . DOI: 10.1038/sj.gene.6364007
Palavras-Chave #/dk/atira/pure/subjectarea/asjc/1300/1311 #Genetics #/dk/atira/pure/subjectarea/asjc/2400/2403 #Immunology #/dk/atira/pure/subjectarea/asjc/2700/2716 #Genetics(clinical)
Tipo

article
Resumo

Variations in the interleukin 4 receptor A (IL4RA) gene have been reported to be associated with atopy, asthma, and allergy, which may occur less frequently in subjects with type 1 diabetes (T1D). Since atopy shows a humoral immune reactivity pattern, and T1D results from a cellular (T lymphocyte) response, we hypothesised that alleles predisposing to atopy could be protective for T1D and transmitted less often than the expected 50% from heterozygous parents to offspring with T1D. We genotyped seven exonic single nucleotide polymorphisms (SNPs) and the -3223 C>T SNP in the putative promoter region of IL4RA in up to 3475 T1D families, including 1244 Finnish T1D families. Only the -3223 C>T SNP showed evidence of negative association (P=0.014). There was some evidence for an interaction between -3233 C>T and the T1D locus IDDM2 in the insulin gene region (P=0.001 in the combined and P=0.02 in the Finnish data set). We, therefore, cannot rule out a genetic effect of IL4RA in T1D, but it is not a major one.
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