Proteomic Analysis of Recurrent Joint Inflammation in Juvenile Idiopathic Arthritis
Data(s) |
01/08/2006
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Resumo |
The synovial fluid proteome in juvenile idiopathic arthritis was investigated to isolate joint-specific biomarkers that are expressed in patients displaying recurrent joint inflammation. To identify the synovial specific proteome, matched synovial fluid and plasma samples were subjected to protein separation by 2-dimension electrophoresis (2DE). Forty-three protein spots, overexpressed in the joint, were identified. Synovial fluids from children with single-event knee joint inflammation were then compared with a group with recurrent knee disease. Nine synovial specific proteins were significantly differentially expressed in the recurrent group. Proteolytic fragments of collagen X, fibrin beta-chain, and T-cell receptor alpha-region have been identified among this protein cluster. Putative biomarkers, overexpressed in the joint and differentially expressed in children with recurrent joint inflammation, have been identified. These proteins may play a significant role determining the pathological state within the chronically inflamed joint and influence disease progression in JIA. This is the first study of the synovial proteome in children. |
Formato |
application/pdf |
Identificador |
http://dx.doi.org/10.1021/pr060129t http://pure.qub.ac.uk/ws/files/390799/proteomic%20analysis%20of%20recurrent.pdf http://www.scopus.com/inward/record.url?scp=33747164203&partnerID=8YFLogxK |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Gibson , D , Blelock , S , Brockbank , S , Curry , J , Healy , A , McAllister , C & Rooney , M 2006 , ' Proteomic Analysis of Recurrent Joint Inflammation in Juvenile Idiopathic Arthritis ' Journal of Proteome Research , vol 5 , no. 8 , pp. 1988-1995 . DOI: 10.1021/pr060129t |
Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/1300/1311 #Genetics #/dk/atira/pure/subjectarea/asjc/1300/1305 #Biotechnology #/dk/atira/pure/subjectarea/asjc/1300/1303 #Biochemistry |
Tipo |
article |