Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism
Data(s) |
15/06/2002
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Resumo |
A side-effect of treatment with antipsychotic drugs for schizophrenia is increased body fat, which leads to further morbidity and poor adherence to treatment. The 5-hydroxytryptamine 2C receptor (5-HT2C) has been associated with this effect; we aimed to establish whether a genetic polymorphism of the promoter region of this receptor affects weight gain after drug treatment in first-episode patients with schizophrenia. We noted significantly less weight gain in patients with the -759T variant allele (p=0.0003) than in those without this allele, who were more likely to have substantial (>7%) weight gain (p=0.002). We have identified a genetic factor that is associated with antipsychotic drug-induced weight gain. |
Identificador |
http://dx.doi.org/10.1016/S0140-6736(02)08913-4 http://www.scopus.com/inward/record.url?scp=0037097014&partnerID=8YFLogxK |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Reynolds , G , Zhang , Z J & Zhang , X B 2002 , ' Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism ' The Lancet , vol 359(9323) , no. 9323 , pp. 2086-2087 . DOI: 10.1016/S0140-6736(02)08913-4 |
Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2700 #Medicine(all) |
Tipo |
article |