Accelerated apoptosis in SLE neutrophils cultured with anti-dsDNA antibody isolated from SLE patient serum: a pilot study.
Data(s) |
01/12/2006
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Resumo |
Increased numbers of apoptotic neutrophils are found in SLE, related to disease activity and levels of anti-dsDNA antibody. The mechanism of increased apoptosis is not clear, but anti-dsDNA antibody has been shown to induce apoptosis in neutrophils from normal subjects and in certain cell lines. In this study, polyclonal anti-dsDNA antibody was isolated from the serum of a patient with active SLE, and was shown to substantially accelerate apoptosis in neutrophils from SLE patients as compared with neutrophils from healthy control or rheumatoid arthritis subjects. |
Formato |
application/msword |
Identificador |
http://dx.doi.org/10.1007/s00296-006-0219-z http://pure.qub.ac.uk/ws/files/340443/Accelerated%20apoptosis%20in%20SLE%20neutrophils.doc http://www.scopus.com/inward/record.url?scp=33846164081&partnerID=8YFLogxK |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Bell , A , Armstrong , D J , Crockard , A D , Wisdom , A D & Whitehead , E 2006 , ' Accelerated apoptosis in SLE neutrophils cultured with anti-dsDNA antibody isolated from SLE patient serum: a pilot study. ' Rheumatol Int , vol 27 , no. 2 , pp. 153-156 . DOI: 10.1007/s00296-006-0219-z |
Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2700/2745 #Rheumatology |
Tipo |
article |