Characterisation of a beta-tubulin gene from the liver fluke, Fasciola hepatica.
Data(s) |
2001
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Resumo |
This study represents the first ß-tubulin sequence from a trematode parasite, namely, the liver fluke, Fasciola hepatica. PCR of genomic DNA showed that at least one ß-tubulin gene from F. hepatica contains no introns. A number of amino acids in the primary sequence of fluke tubulin are different from those described previously in various nematode species and the cestode, Echinococcus multilocularis. ß-Tubulin is an important target for benzimidazole anthelmintics, although (with the exception of triclabendazole) they show limited activity against F. hepatica. The amino acid differences in fluke ß-tubulin are discussed in relation to the selective toxicity of benzimidazoles against helminths and the mechanism of drug resistance. |
Identificador |
http://dx.doi.org/10.1016/S0020-7519(01)00240-5 http://www.scopus.com/inward/record.url?scp=0034893162&partnerID=8YFLogxK |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Hoey , E , Robinson , M , Fairweather , I , Dalton , J P , McGonigle , S & Trudgett , A 2001 , ' Characterisation of a beta-tubulin gene from the liver fluke, Fasciola hepatica. ' International Journal for Parasitology , vol 31(11) , no. 11 , pp. 1264-1268 . DOI: 10.1016/S0020-7519(01)00240-5 |
Palavras-Chave | #/dk/atira/pure/subjectarea/asjc/2400/2405 #Parasitology #/dk/atira/pure/subjectarea/asjc/2700/2725 #Infectious Diseases |
Tipo |
article |