Identifying Barriers and Practical Solutions to Conducting Site-Based Research in North America: Exploring Acute Heart Failure Trials As a Case Study.


Autoria(s): Ambrosy, AP; Mentz, RJ; Krishnamoorthy, A; Greene, SJ; Severance, HW
Data(s)

01/10/2015

Formato

581 - 589

Identificador

http://www.ncbi.nlm.nih.gov/pubmed/26462098

S1551-7136(15)00055-0

Heart Fail Clin, 2015, 11 (4), pp. 581 - 589

1551-7136

http://hdl.handle.net/10161/11505

Relação

Heart Fail Clin

10.1016/j.hfc.2015.07.002

Palavras-Chave #Acute heart failure #Clinical trials #Site-based research #Acute Disease #Clinical Trials as Topic #Guideline Adherence #Heart Failure #Humans #North America #Research #Research Design
Tipo

Journal Article

Cobertura

United States

Resumo

Although the prognosis of ambulatory heart failure (HF) has improved dramatically there have been few advances in the management of acute HF (AHF). Despite regional differences in patient characteristics, background therapy, and event rates, AHF clinical trial enrollment has transitioned from North America and Western Europe to Eastern Europe, South America, and Asia-Pacific where regulatory burden and cost of conducting research may be less prohibitive. It is unclear if the results of clinical trials conducted outside of North America are generalizable to US patient populations. This article uses AHF as a paradigm and identifies barriers and practical solutions to successfully conducting site-based research in North America.

Idioma(s)

ENG