Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak.
Data(s) |
01/12/2015
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Formato |
810 - 816 |
Identificador |
http://www.ncbi.nlm.nih.gov/pubmed/26542222 S1472-9792(15)30145-1 Tuberculosis (Edinb), 2015, 95 (6), pp. 810 - 816 http://hdl.handle.net/10161/11176 1873-281X |
Relação |
Tuberculosis (Edinb) 10.1016/j.tube.2015.09.001 |
Palavras-Chave | #Beijing strains #Central America #Guatemala #Molecular epidemiology #Tuberculosis #Whole genome sequencing #China #DNA, Bacterial #Databases, Genetic #Disease Outbreaks #Genome, Bacterial #Genotype #Guatemala #Humans #Molecular Epidemiology #Mycobacterium tuberculosis #Phenotype #Phylogeny #Polymorphism, Single Nucleotide #Poverty #Predictive Value of Tests #Sequence Analysis, DNA #Tuberculosis #Urban Health |
Tipo |
Journal Article |
Cobertura |
Scotland |
Resumo |
Limited data are available regarding the molecular epidemiology of Mycobacterium tuberculosis (Mtb) strains circulating in Guatemala. Beijing-lineage Mtb strains have gained prevalence worldwide and are associated with increased virulence and drug resistance, but there have been only a few cases reported in Central America. Here we report the first whole genome sequencing of Central American Beijing-lineage strains of Mtb. We find that multiple Beijing-lineage strains, derived from independent founding events, are currently circulating in Guatemala, but overall still represent a relatively small proportion of disease burden. Finally, we identify a specific Beijing-lineage outbreak centered on a poor neighborhood in Guatemala City. |
Idioma(s) |
ENG |