Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events.
Data(s) |
01/04/2010
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Formato |
207 - 214 |
Identificador |
http://www.ncbi.nlm.nih.gov/pubmed/20173117 CIRCGENETICS.109.852814 Circ Cardiovasc Genet, 2010, 3 (2), pp. 207 - 214 http://hdl.handle.net/10161/5964 1942-3268 |
Relação |
Circ Cardiovasc Genet 10.1161/CIRCGENETICS.109.852814 Circulation: Cardiovasular Genetics |
Palavras-Chave | #Adult #Aged #Biomarkers #Coronary Artery Disease #Female #Humans #Linear Models #Male #Mass Spectrometry #Metabolome #Middle Aged #Myocardial Infarction #Odds Ratio #Principal Component Analysis #Proportional Hazards Models #ROC Curve #Risk Factors |
Tipo |
Journal Article |
Cobertura |
United States |
Resumo |
BACKGROUND: Molecular tools may provide insight into cardiovascular risk. We assessed whether metabolites discriminate coronary artery disease (CAD) and predict risk of cardiovascular events. METHODS AND RESULTS: We performed mass-spectrometry-based profiling of 69 metabolites in subjects from the CATHGEN biorepository. To evaluate discriminative capabilities of metabolites for CAD, 2 groups were profiled: 174 CAD cases and 174 sex/race-matched controls ("initial"), and 140 CAD cases and 140 controls ("replication"). To evaluate the capability of metabolites to predict cardiovascular events, cases were combined ("event" group); of these, 74 experienced death/myocardial infarction during follow-up. A third independent group was profiled ("event-replication" group; n=63 cases with cardiovascular events, 66 controls). Analysis included principal-components analysis, linear regression, and Cox proportional hazards. Two principal components analysis-derived factors were associated with CAD: 1 comprising branched-chain amino acid metabolites (factor 4, initial P=0.002, replication P=0.01), and 1 comprising urea cycle metabolites (factor 9, initial P=0.0004, replication P=0.01). In multivariable regression, these factors were independently associated with CAD in initial (factor 4, odds ratio [OR], 1.36; 95% CI, 1.06 to 1.74; P=0.02; factor 9, OR, 0.67; 95% CI, 0.52 to 0.87; P=0.003) and replication (factor 4, OR, 1.43; 95% CI, 1.07 to 1.91; P=0.02; factor 9, OR, 0.66; 95% CI, 0.48 to 0.91; P=0.01) groups. A factor composed of dicarboxylacylcarnitines predicted death/myocardial infarction (event group hazard ratio 2.17; 95% CI, 1.23 to 3.84; P=0.007) and was associated with cardiovascular events in the event-replication group (OR, 1.52; 95% CI, 1.08 to 2.14; P=0.01). CONCLUSIONS: Metabolite profiles are associated with CAD and subsequent cardiovascular events. |
Idioma(s) |
ENG |