Adjuvant therapy in elderly patients with breast cancer.


Autoria(s): Biganzoli, Laura; Aapro, Matti; Balducci, Lodovico; Crivellari, Diana; Minisini, A; Piccart-Gebhart, Martine
Data(s)

01/08/2004

Resumo

The elderly population has been neglected by the traditional approach to clinical breast cancer research. Elderly women have been underrepresented in breast cancer clinical trials, with the majority of studies being restricted to patients aged < 70 years. Elderly patients frequently have comorbidities and/or impaired organ function. These facts may often lead to death from causes other than cancer, thus nullifying any possible benefit of adjuvant treatment; furthermore, they render extrapolation of standard treatment recommendations to the elderly potentially hazardous, particularly with respect to chemotherapy. Therefore, specific clinical trials are needed to investigate adjuvant treatments tailored for the heterogeneous older population.

Journal Article

Review

info:eu-repo/semantics/published

Formato

No full-text files

Identificador

uri/info:pmid/15335450

http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/55252

Idioma(s)

en

Fonte

Clinical breast cancer, 5 (3

Palavras-Chave #Sciences bio-médicales et agricoles #Age Factors #Aged #Antineoplastic Agents -- administration & dosage #Breast Neoplasms -- drug therapy #Chemotherapy, Adjuvant #Clinical Trials as Topic #Female #Geriatric Assessment #Humans #Middle Aged #Patient Selection
Tipo

info:eu-repo/semantics/article

info:ulb-repo/semantics/articlePeerReview

info:ulb-repo/semantics/openurl/article