'Adipaging': Aging and obesity share biological hallmarks related to a dysfunctional adipose tissue
Data(s) |
07/03/2016
07/03/2016
2016
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Resumo |
The increasing aging of our societies is accompanied by a pandemic of obesity and related cardiometabolic disorders. Progressive dysfunction of the white adipose tissue is increasingly recognized as an important hallmark of the aging process which in turn contributes to metabolic alterations, multi-organ damage, and a systemic pro-inflammatory state ('inflammaging'). On the other hand, obesity, the paradigm of adipose tissue dysfunction, shares numerous biological similarities with the normal aging process such as chronic inflammation and multi-system alterations. Accordingly, understanding the interplay between accelerated aging related to obesity and adipose tissue dysfunction is critical to gain insight into the aging process in general as well as into the pathophysiology of obesity and other related conditions. Here we postulate the concept of 'adipaging' to illustrate the common links between aging and obesity and the fact that, to a great extent, obese adults are prematurely aged individuals. SAF 2010-15239 SAF2015-67911 4.731 JCR (2015) Q1, 7/83 Physiology, 46/256 Neurosciences UEM |
Identificador |
Pérez, L. M., Pareja-Galeano, H., Sanchís-Gomar, F., Emanuele, E., Lucía, A., & González Gálvez, B. (2016). 'Adipaging': Aging and obesity share biological hallmarks related to a dysfunctional adipose tissue. Journal of Physiology, 594(12), 3187-207. DOI: 10.1113/JP271691 14697793 00223751 http://hdl.handle.net/11268/5007 10.1113/JP271691 |
Idioma(s) |
eng |
Direitos |
openAccess |
Palavras-Chave | #Conducta alimentaria #Obesidad #Obesidad |
Tipo |
article |