The chemical constituents from red alga Gymnogongrus flabelliformis Harv.
Data(s) |
01/05/2008
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Resumo |
Eight compounds were isolated from red alga Gymnogongrus flabelliformis Harv. In normal phase silica gel, Sephadex LH-20 gel column chromatography, reverse phase HPLC, and recrystallization. Based on MS and 1D NMR spectroscopic data, their structures were determined as: stigmast-4-en-3-one (I), cholest-4-en-3-one (II), cholesterol (III), uracil (IV), uridine (V), adenosine (VI), succinic acid (VII), and 5-hydroxy-4-methyl-5-pentyl-2,5-dihydro-furan-2-on (VIII). All of them were obtained from this species for the first time. Cytotoxicity of these compounds was screened using standard MTT method, but all the compounds were inactive (IC50 > 10 mu g/ml). Eight compounds were isolated from red alga Gymnogongrus flabelliformis Harv. In normal phase silica gel, Sephadex LH-20 gel column chromatography, reverse phase HPLC, and recrystallization. Based on MS and 1D NMR spectroscopic data, their structures were determined as: stigmast-4-en-3-one (I), cholest-4-en-3-one (II), cholesterol (III), uracil (IV), uridine (V), adenosine (VI), succinic acid (VII), and 5-hydroxy-4-methyl-5-pentyl-2,5-dihydro-furan-2-on (VIII). All of them were obtained from this species for the first time. Cytotoxicity of these compounds was screened using standard MTT method, but all the compounds were inactive (IC(50) > 10 mu g/ml). |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Yuan Zhaohui; Han Lijun; Su Hua; Shi Dayong; Sun Jie; Li Shuai; Shi Jiangong.The chemical constituents from red alga Gymnogongrus flabelliformis Harv.,CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2008,26(2):190-192 |
Palavras-Chave | #Limnology; Oceanography #red algae #Gymnogongrus flabelliformis Harv. #chemical constituents #MTT assay |
Tipo |
期刊论文 |