Steroids from green alga Chaetomorpha basiretorsa Setchell
Data(s) |
01/11/2008
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Resumo |
Six steroids have been isolated from ethanolic extract of green alga Chaetomorpha basiretorsa Setchell by a combination of repeated normal phase silica gel and Sephadex LH-20 gel column chromatography as well as recrystallization. Using spectroscopic methods including MS and NMR, their structures were determined as beta-lawsaritol (1), saringosterol (2), 24-hydroperoxy-24-vinyl-cholesterol (3), beta-stigmasterol (4), stigmast-4-en-3 alpha, 6 beta-diol (5), 29-hydroxystigmasta-5, 24 (28)-dien-3 beta-ol (6). All these compounds were obtained from this genus for the first time and they were inactive (IC50 > 10 mu g /ml) against KB, Bel-7402, PC-3M, Ketr 3 and MCF-7 cell lines. Six steroids have been isolated from ethanolic extract of green alga Chaetomorpha basiretorsa Setchell by a combination of repeated normal phase silica gel and Sephadex LH-20 gel column chromatography as well as recrystallization. Using spectroscopic methods including MS and NMR, their structures were determined as beta-lawsaritol (1), saringosterol (2), 24-hydroperoxy-24-vinyl-cholesterol (3), beta-stigmasterol (4), stigmast-4-en-3 alpha, 6 beta-diol (5), 29-hydroxystigmasta-5, 24 (28)-dien-3 beta-ol (6). All these compounds were obtained from this genus for the first time and they were inactive (IC(50)> 10 mu g /ml) against KB, Bel-7402, PC-3M, Ketr 3 and MCF-7 cell lines. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Shi Dayong; Fan Xiao; Sun Jie; Han Lijun; Shi Jiangong.Steroids from green alga Chaetomorpha basiretorsa Setchell,CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2008,26(4):415-418 |
Palavras-Chave | #Limnology; Oceanography #green alga #Chaetomorpha basiretorsa Setchell #steroids |
Tipo |
期刊论文 |