Biodegradable electrospun fibers for drug delivery
Data(s) |
2003
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Resumo |
The influences of surfactants and medical drugs on the diameter size and uniformity of electrospun poly(L-lactic acid) (PLLA) fibers were examined by adding various surfactants (cationic, anionic, and nonionic) and typical drugs into the PLLA solution. Significant diameter reduction and uniformity improvement were observed. It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers. Such ultrafine fiber mats containing drugs may find clinical applications in the future. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Zeng J;Xu XY;Chen XS;Liang QZ;Bian XC;Yang LX;Jing XB.Biodegradable electrospun fibers for drug delivery,JOURNAL OF CONTROLLED RELEASE,2003,92(3):227-231 |
Palavras-Chave | #POLYMER TEMPLATE FIBERS #DIAMETER FIBERS #NANOFIBERS #JETS |
Tipo |
期刊论文 |