Synthesis and evaluation of novel polysaccharide-Gd-DTPA compounds as contrast agent for MRI
Data(s) |
2003
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Resumo |
Macromolecular conjugates of two kinds of natural polysaccharides, that from Panax quinquefolium linn (PQPS) and Ganoderma applanatum pat (GAPS), with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) have been synthesized and characterized by means of FTIR, elementary analysis and ICP-AES. Their stability was investigated by competition study with Ca2+, EDTA (ethylenediaminetetraacetic acid) and DTPA. Polysaccharide-bound complexes exhibit T-1 relaxivities of 1.5-1.7 times that of Gd-DTPA in D2O at 25degreesC and 9.4T. MR imaging of Sprague-Dawley (SD) rats showed remarkable enhancement in rat liver and kidney after i.v. injection of these two complexes: liver parenchyma 60.9+/-5.6%, 57.8+/-7.4% at 65-85 min; kidney 144.9+/-14.5%, 199.9+/-25.4% at 10-30 min for PQPS-GdDTPA, GAPS-Gd-DTPA at gadolinium dose of 0.083 and 0.082 mmol/kg, respectively. Our preliminary in vivo and in vitro study indicates that the two kinds of polysaccharide-bound complexes are potential tissue-specific contrast agents for MRI. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Sun GY;Feng JH;Jing FY;Pei FK;Liu ML.Synthesis and evaluation of novel polysaccharide-Gd-DTPA compounds as contrast agent for MRI,JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS,2003,265(2):123-129 |
Palavras-Chave | #MAGNETIC-RESONANCE #SERUM-ALBUMIN #GADOLINIUM(III) #RELAXATION #DEXTRAN #BIODISTRIBUTION #DERIVATIVES #MODEL #ACID |
Tipo |
期刊论文 |