Enantioselective iodolactonization catalyzed by chiral quaternary ammonium salts derived from cinchonidine
Data(s) |
2004
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Resumo |
Chiral quaternary ammonium salts derived from cinchonidine have been applied to catalyze the stereoselective iodolactonizations of trans-5-aryl-4-pentenoic acids leading to a mixture of two regioselectively iodolactonized products with fair to excellent yield (37-98%) and moderate enantioselectivity (exo = 42.0% ee, endo = 31.0% ee) under mild conditions. This work is the first example of asymmetric iodolactonization reaction in the presence of less than a stoichiometric amount of chiral reagent. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Wang M;Gao LX;Mai WP;Xia AX;Wang F;Zhang SB.Enantioselective iodolactonization catalyzed by chiral quaternary ammonium salts derived from cinchonidine,JOURNAL OF ORGANIC CHEMISTRY,2004,69(8 ):2874-2876 |
Palavras-Chave | #AUXILIARY #PHASE #3 #5-DISUBSTITUTED-GAMMA-BUTYROLACTONES #HALOCYCLIZATION #AMIDES |
Tipo |
期刊论文 |