Sugars-grafted aliphatic biodegradable poly(L-lactide-co-carbonate)s by click reaction and their specific interaction with lectin molecules


Autoria(s): Lu CH; Shi Q; Chen XS; Lu TC; Xie ZG; Hu XL; Ma J; Jing XB
Data(s)

2007

Resumo

A novel biodegradable aliphatic poly(L-lactide-co-carbonate) bearing pendant acetylene groups was successfully prepared by ring-opening copolymerization of L-lactide (LA) with 5-methyl-5-propargyloxycarbonyl-1,3-dioxan-2-one (PC) in the presence of benzyl alcohol as initiator with ZnEt2 as catalyst in bulk at 100 degrees C and subsequently used for grafting 2-azidoethyl beta-D-glucopyranoside and 2-azidoethyl beta-lactoside by the typical "click reaction," that is Cu(I)-catalyzed cycloaddition of azide and alkyne. The density of acetylene groups in the copolymer can be tailored by the molar ratio of PC to LA during the copolymerization. The aliphatic copolymers grafted with sugars showed low cytotoxicity to L929 cells, improved hydrophilic properties and specific recognition and binding ability with lectins, that is Concanavalin A (Con A) and Ricinus communis agglutinin (RCA). Therefore, this kind of sugar-grafted copolymer could be a good candidate in variety of biomedical applications.

Identificador

http://ir.ciac.jl.cn/handle/322003/14391

http://www.irgrid.ac.cn/handle/1471x/150150

Idioma(s)

英语

Fonte

Lu CH;Shi Q;Chen XS;Lu TC;Xie ZG;Hu XL;Ma J;Jing XB.Sugars-grafted aliphatic biodegradable poly(L-lactide-co-carbonate)s by click reaction and their specific interaction with lectin molecules,JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2007 ,45(15):3204-3217

Palavras-Chave #RING-OPENING POLYMERIZATION #INFLUENZA-VIRUS #BLOCK-COPOLYMER #LIGAND RECOGNITION #CYCLIC CARBONATE #CONCANAVALIN-A #L-LACTIDE #POLYESTERS #BINDING #ACID
Tipo

期刊论文