Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum
Data(s) |
2008
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Resumo |
Cinnabar, an important traditional Chinese mineral medicine, has been widely used as a Chinese patent medicine ingredient for sedative therapy. However, the pharmaceutical and toxicological effects of cinnabar, especially in the whole organism, were subjected to few investigations. In this study, an NMR-based metabolomics approach has been applied to investigate the toxicological effects of cinnabar after intragastrical administration (dosed at 0.5, 2 and 5 g/kg body weight) on male Wistar rats. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
Wei L;Liao PQ;Wu HF;Li XJ;Pei FK;Li WS;Wu YJ.Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum,TOXICOLOGY AND APPLIED PHARMACOLOGY,2008,227(3 ):417-429 |
Palavras-Chave | #MAGNETIC-RESONANCE-SPECTROSCOPY #LIVER TAURINE LEVELS #PATTERN-RECOGNITION #OXIDATIVE STRESS #MERCURIC SULFIDE #HEPATOTOXIC COMPOUNDS #SYSTEMS BIOLOGY #DRUG TOXICITY #RENAL DAMAGE #METABONOMICS |
Tipo |
期刊论文 |