Capillary zone electrophoresis investigation of the interaction between heparin and granulocyte-colony stimulating factor
Data(s) |
01/03/2004
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Resumo |
The interaction between standard heparin, low-molecular-weight heparin (LMWH), and granulocyte-colony stimulating factor (G-CSF) was studied by capillary zone electrophoresis. Both qualitative and quantitative characterizations of the heparin-protein binding were determined. The binding constants of the two different groups of heparins with G-CSF, calculated from the Scatchard plot by regression, were 4.805 x 10(5) m(-1) and 4.579 x 10(5) m(-1), respectively. The two binding constants measured are of the same order of magnitude at 10(5) m(-1), indicating that LMWH contains most of the functional groups bound to G-CSF by standard heparin. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
梁爱叶;何新亚;杜昱光;王克夷;冯应升;林炳承.Capillary Zone Electrophoresis Investigation of the Interaction Between Heparin and Granulocyte-colony Stimulating Factor,Electrophoresis,2004,25(6):870-875 |
Palavras-Chave | #capillary zone electrophoresis #granulocyte-colony stimulating factor #heparin |
Tipo |
期刊论文 |