A correlation between radiation sensitivity and initial chromatid breaks in cancer cell lines revealed by Calyculin A-induced premature condensation
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3896
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Resumo |
Three human malignancy cell lines were irradiated with Co-60 gamma-rays. Initial chromatid breaks were measured by using the chemically induced premature chromosome condensation technique. Survival curves of cells exposed to gamma rays was linear-quadratic while the efficiency of Calyculin A in inducing PCC of G(2) PCC was about five times more than G(1) PCC. A dose-dependent increase in radiation-induced chromatid/isochromatid breaks was observed in G(1) and G(2) phase PCC and a nearly positive linear correlation was found between cell survival and chromatin breaks. This study implies that low LET radiation-induced chromatid/isochromatid breaks can potentially be used to predict the radiosensitivity of tumor cells either in in vitro experimentation or in in vivo clinical radiotherapy. |
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Idioma(s) |
英语 |
Fonte |
Yang, JS (Yang Jianshe); Jing, XG (Jing Xigang); Wang, ZZ (Wang Zhuanzi); Li, WJ (Li Wenjian) .A correlation between radiation sensitivity and initial chromatid breaks in cancer cell lines revealed by Calyculin A-induced premature condensation,CENTRAL EUROPEAN JOURNAL OF BIOLOGY,38961,1(3):451-462 |
Palavras-Chave | #radiation sensitivity #chromatid break #cancer cell #Calyculin A #premature chromosome condensation |
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期刊论文 |