HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma
Data(s) |
2003
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Resumo |
AIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal carcinoma in Han Chinese in Hubei Province. METHODS: HLA-DRB1 allele polymorphisms were typed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 42 unrelated patients with esophageal cancer and 136 unrelated normal control subjects and the associated HLA-DRB1 allele was measured by nucleotide sequence analysis with PCR.SAS software was used in statistics. RESULTS: Allele frequency (AF) of HLA-DRB1*0901 was significantly higher in esophageal carcinoma patients than that in the normal controls (0.2500 vs0.1397, P=0.028, the odds ratio 2.053, etiologic fraction 0.1282). After analyzed the allele nucleotide sequence of HLA-DRB1*0901 which approachs to the corresponded exon 2 sequence of the allele in genebank. There was no association between patients and controls in the rested HLA-DRB1 alleles. CONCLUSION: HLA-DRB1*0901 allele is more common in the patients with esophageal carcinoma than in the healthy controls, which is positively associated with the patients of Hubei Han Chinese. Individuals carrying HLA-DRB1*0901 may be susceptible to esophageal carcinoma. |
Identificador | |
Idioma(s) |
英语 |
Fonte |
.HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma,WORLD JOURNAL OF GASTROENTEROLOGY,2003,9(3):412-416 |
Palavras-Chave | #Gastroenterology & Hepatology #HLA CLASS-II |
Tipo |
期刊论文 |