Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction
Data(s) |
2004
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Resumo |
Large intestinal obstruction (LIO) in farm animals can cause a ischaemic necrosis of intestinal tissue, eventually leading to death. The roles of endothelin-1 (ET-1) and nitric oxide (NO) are not well understood in the process of LIO, but evidence suggests that endothelial-derived mediators may participate. In the present study, ET-1 concentration and total nitric oxide synthase (NOS) activity were measured in heart, liver, pancreas, lung and kidney in a model of LIO in sheep. Our data demonstrated that ET-1 concentration and NOS activity were altered, with significant increases of ET-1 in heart, lung and kidney and of NOS activity in pancreas and kidney, but a marked decline of NOS activity in liver (p<0.05). It is postulated that these alterations in NOS activity and ET-1 concentration may contribute to the progressive loss of organ function, and finally lead to death in LIO in sheep. |
Identificador | |
Direitos |
Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction |
Fonte |
Li, XL; Su, L.Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction,28,719-725,(SCI-E ): |
Palavras-Chave | #Veterinary Sciences |
Tipo |
期刊论文 |