Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval

D-Serine, the endogenous coagonist of N-methyl-D-aspartate receptors (NMDARs), is considered to be an important gliotransmitter, and is essential for the induction of long-term potentiation. However, less is known about the role of D-serine in another for

National Natural Science Foundation of China (No. 30621062); the National Basic Research Program of China (No. 2006CB500803); and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35).