D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75

Integration of viral-DNA into host chromosome mediated by the viral protein HIV-1 integrase (IN) is an essential step in the HIV-1 life cycle. In this process, Lens epithelium-derived growth factor (LEDGF/p75) is discovered to function as a cellular co-fa

We thank Prof. Zeger Debyser (Katholieke Universiteit Leuven) for kindly offering the plasmid pCPNat p75. This work was financially Supported by the National Natural Science Foundation of China (Grants Nos. 30525024, 20472095, 20572023), the National "863