A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima
Data(s) |
2002
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Resumo |
A novel bombesin-related peptide was isolated from skin secretions of Chinese red belly toad Bombina maxima. Its primary structure was established as pGlu-Lys-Lys-Pro-Pro-Arg-Pro-Pro-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2. The amino-terminal (N-terminal) 8-residue segment comprising four prolines and three basic residues is extensively different from bombesins from other Bombina species. The peptide was thus named proline rich bombesin (PR-bombesin). PR-bumbesin was found to elicit concentration-dependent contractile effects in the rat stomach strip, with both increased potency and intrinsic activity as compared with those of [Leu(13)]bombesin. Analysis of different bombesin cDNA structures revealed that an 8 to 14- nucleotide fragment replacement in the peptide coding region (TGGGGAAT in the cDNAs of multiple bombesin forms from Bombina orientalis and CACCCCGGCCACCC in the cDNA of PR-bombesin) resulted in an unusual Pro-Pro-Arg-Pro-Pro motif in the N-terminal part of PR-bombesin. (C) 2002 Elsevier Science Inc. All rights reserved. |
Identificador | |
Direitos |
A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima |
Fonte |
Lai, R; Liu, H; Lee, WH; Zhang, Y.A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima,23,437-442,(SCI-E): |
Palavras-Chave | #Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
Tipo |
期刊论文 |