Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients


Autoria(s): Querido, Jailson F. B.; Echeverría, María G.; Martí, Gerardo A.; Medina Costa, Rita; Susevich, María L.; Rabinovich, Jorge E.; Copa, Aydee; Montaño, Nair A.; Garcia, Lineth; Cordova, Marisol; Torrico, Faustino; Sánchez Eugenia, Rubén; Sánchez Magraner, Lissete; Muñiz Trabudua, Xabier; López Marijuan, Ibai; Rozas-Dennis, Gabriela S.; Diosque, Patricio; de Castro, Ana M.; Robello, Carlos; Rodríguez, Julio S.; Altcheh, Jaime; Salazar-Schettino, Paz M.; Bucio, Marta I.; Espinoza, Bertha; Guérin Silva, Diego M. A.
Data(s)

06/05/2016

06/05/2016

17/01/2015

Resumo

Background: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake. Methods: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015. Results: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts. Conclusions: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.

Identificador

Parasites & Vectors 8 2015 : (2015) // Article ID UNSP 29

1756-3305

http://hdl.handle.net/10810/18179

10.1186/s13071-015-0632-9

Idioma(s)

eng

Publicador

Biomed Central

Relação

http://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-015-0632-9#Abs1

Direitos

© 2015 Querido et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated

info:eu-repo/semantics/openAccess

Palavras-Chave #triatoma virus #dicistroviridae #trypanosoma cruzi #triatomines #chagas disease #mathematical model #biological control #passive viral exposure #infestans hemiptera #reduviidae #transmission #argentina #TRV #particles
Tipo

info:eu-repo/semantics/article