Depression of Serotonin Synaptic Transmission by the Dopamine Precursor L-DOPA
Data(s) |
07/04/2016
07/04/2016
11/08/2015
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Resumo |
Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson's disease (PD) and psychiatric disorders. L-DOPA, the leading treatment of PD, facilitates the production and release of dopamine. This study assessed the action of L-DOPA on monoamine synaptic transmission in mouse brain slices. Application of L-DOPA augmented the D2-receptor-mediated inhibitory postsynaptic current (IPSC) in dopamine neurons of the substantia nigra. This augmentation was largely due to dopamine release from 5-HT terminals. Selective optogenetic stimulation of 5-HT terminals evoked dopamine release, producing D2-receptor-mediated IPSCs following treatment with L-DOPA. In the dorsal raphe, L-DOPA produced a long-lasting depression of the 5-HT1A-receptor-mediated IPSC in 5-HT neurons. When D2 receptors were expressed in the dorsal raphe, application of L-DOPA resulted in a D2-receptor-mediated IPSC. Thus, treatment with L-DOPA caused ectopic dopamine release from 5-HT terminals and a loss of 5-HT-mediated synaptic transmission. |
Identificador |
Cell Reports 12(6) 2014 : 944-954 (2014) // Article ID j.celrep.2015.07.005 2211-1247 http://hdl.handle.net/10810/17824 10.1016/j.celrep.2015.07.005 |
Idioma(s) |
eng |
Publicador |
Cell Press |
Relação |
http://www.sciencedirect.com/science/article/pii/S2211124715007317 |
Direitos |
© 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). info:eu-repo/semantics/openAccess |
Palavras-Chave | #rat substantia-nigra #dorsal raphe nucleus #parinsons-disease #cerbrospinal-fluid #induced dyskinesia #amino-acid #in-vitro #neurons #receptor #release |
Tipo |
info:eu-repo/semantics/article |