Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia
Data(s) |
07/02/2014
07/02/2014
01/01/2013
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Resumo |
Overexpression of the mammalian homolog of the unc-18 gene (munc18-1) has been described in the brain of subjects with schizophrenia. Munc18-1 protein is involved in membrane fusion processes, exocytosis and neurotransmitter release. A transgenic mouse strain that overexpresses the protein isoform munc18-1a in the brain was characterized. This animal displays several schizophrenia-related behaviors, supersensitivity to hallucinogenic drugs and deficits in prepulse inhibition that reverse after antipsychotic treatment. Relevant brain areas (that is, cortex and striatum) exhibit reduced expression of dopamine D-1 receptors and dopamine transporters together with enhanced amphetamine-induced in vivo dopamine release. Magnetic resonance imaging demonstrates decreased gray matter volume in the transgenic animal. In conclusion, the mouse overexpressing brain munc18-1a represents a new valid animal model that resembles functional and structural abnormalities in patients with schizophrenia. |
Identificador |
Translational Psychiatry 3 : (2013) // e221 2158-3188 http://hdl.handle.net/10810/11384 10.1038/tp.2012.149 |
Idioma(s) |
eng |
Publicador |
Nature Publishing Group |
Relação |
http://www.nature.com/tp/journal/v3/n1/full/tp2012149a.html |
Direitos |
(c)2013 Urigüen et al. This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/. info:eu-repo/semantics/openAccess |
Palavras-Chave | #munc18-1a #PPI #schizophrenia #SNARE |
Tipo |
info:eu-repo/semantics/article |