Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research


Autoria(s): Mata, Elena; Salvador Martínez, Aiala; Igartua Olaechea, Manuela; Hernández Martín, Rosa María; Pedraz Muñoz, José Luis
Data(s)

05/02/2014

05/02/2014

2013

Resumo

There is no malaria vaccine currently available, and the most advanced candidate has recently reported a modest 30% efficacy against clinical malaria. Although many efforts have been dedicated to achieve this goal, the research was mainly directed to identify antigenic targets. Nevertheless, the latest progresses on understanding how immune system works and the data recovered from vaccination studies have conferred to the vaccine formulation its deserved relevance. Additionally to the antigen nature, the manner in which it is presented (delivery adjuvants) as well as the immunostimulatory effect of the formulation components (immunostimulants) modulates the immune response elicited. Protective immunity against malaria requires the induction of humoral, antibody-dependent cellular inhibition (ADCI) and effector and memory cell responses. This review summarizes the status of adjuvants that have been or are being employed in the malaria vaccine development, focusing on the pharmaceutical and immunological aspects, as well as on their immunization outcomings at clinical and preclinical stages.

Identificador

Biomed Research International 2013 : (2013) //Article ID 282913

2314-6133

http://hdl.handle.net/10810/11355

10.1155/2013/282913

Idioma(s)

eng

Publicador

Hindawi Publishing Corporation

Relação

http://www.hindawi.com/journals/bmri/2013/282913/

Direitos

© 2013 Elena Mata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

info:eu-repo/semantics/openAccess

Palavras-Chave #falciparum circumsporozoite protein #toll like receptors #T-cell responses #merozoite surface protein-1 #virus like particles #biogradable polymer microspheres #inflamatory dendritic cells #enchancesprotective immunity #prime boos immunization #acid sulfate esters
Tipo

info:eu-repo/semantics/article