Scaling law characterizing the dynamics of the transition of HIV-1 to error catastrophe
Data(s) |
2015
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Resumo |
Increasing the mutation rate, mu, of viruses above a threshold, mu(c), has been predicted to trigger a catastrophic loss of viral genetic information and is being explored as a novel intervention strategy. Here, we examine the dynamics of this transition using stochastic simulations mimicking within-host HIV-1 evolution. We find a scaling law governing the characteristic time of the transition: tau approximate to 0.6/(mu - mu(c)). The law is robust to variations in underlying evolutionary forces and presents guidelines for treatment of HIV-1 infection with mutagens. We estimate that many years of treatment would be required before HIV-1 can suffer an error catastrophe. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/52639/1/Phy_Bio_12-5_054001_2015.pdf Gupta, Vipul and Dixit, Narendra M (2015) Scaling law characterizing the dynamics of the transition of HIV-1 to error catastrophe. In: PHYSICAL BIOLOGY, 12 (5). |
Publicador |
IOP PUBLISHING LTD |
Relação |
http://dx.doi.org/10.1088/1478-3975/12/5/054001 http://eprints.iisc.ernet.in/52639/ |
Palavras-Chave | #Chemical Engineering |
Tipo |
Journal Article PeerReviewed |