RNA nucleosides as chiral sensing agents in NMR spectroscopy
Data(s) |
2015
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Resumo |
The study reports chiral sensing properties of RNA nucleosides. Adenosine, guanosine, uridine and cytidine are used as chiral derivatizing agents to differentiate chiral 1 degrees-amines. A three component protocol has been adopted for complexation of nucleosides and amines. The chiral differentiating ability of nucleosides is examined for different amines based on the H-1 NMR chemical shift differences of diastereomers (Delta delta(R,S)). Enantiomeric differentiation has been observed at multiple chemically distinct proton sites. Adenosine and guanosine exhibit large chiral differentiation (Delta delta(R,S)) due to the presence of a purine ring. The diastereomeric excess (de) measured by using adenosine is in good agreement with the gravimetric values. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/51969/1/Org_Bio_Che_13-26_7230_2015.pdf Lokesh, N and Sachin, SL and Narendra, LV and Aruna, K and Suryaprakash, N (2015) RNA nucleosides as chiral sensing agents in NMR spectroscopy. In: ORGANIC & BIOMOLECULAR CHEMISTRY, 13 (26). pp. 7230-7235. |
Publicador |
ROYAL SOC CHEMISTRY |
Relação |
http://dx.doi.org/10.1039/c5ob00513b http://eprints.iisc.ernet.in/51969/ |
Palavras-Chave | #NMR Research Centre (Formerly SIF) #Solid State & Structural Chemistry Unit |
Tipo |
Journal Article PeerReviewed |