A metal-free and a solvent-free synthesis of thio-amides and amides: an efficient Friedel-Crafts arylation of isothiocyanates and isocyanates


Autoria(s): Varun, Begur Vasanthkumar; Sood, Ankush; Prabhu, Kandikere Ramaiah
Data(s)

2014

Resumo

A rapid, metal-free and solvent-free (very low loading of solvent in few cases) reaction conditions for synthesizing thioamides and amides using a Bronsted super acid such as triflic acid has been developed. This method shows a broad substrate scope with a variety of electron-rich arenes including thiophene derivatives. The reaction works well for both aromatic as well as aliphatic isothiocyanates. Most of the thioamides are obtained in excellent yields in short reaction times and in most of the examples, a simple work up procedure has been developed which does not require further purification.

Formato

application/pdf

Identificador

http://eprints.iisc.ernet.in/50617/1/rsc_adv_4-105_60798_2014.pdf

Varun, Begur Vasanthkumar and Sood, Ankush and Prabhu, Kandikere Ramaiah (2014) A metal-free and a solvent-free synthesis of thio-amides and amides: an efficient Friedel-Crafts arylation of isothiocyanates and isocyanates. In: RSC ADVANCES, 4 (105). pp. 60798-60807.

Publicador

ROYAL SOC CHEMISTRY

Relação

http://dx.doi.org/ 10.1039/c4ra12944j

http://eprints.iisc.ernet.in/50617/

Palavras-Chave #Organic Chemistry
Tipo

Journal Article

PeerReviewed