Alkyl chain substituted 1,9-pyrazoloanthrones exhibit prominent inhibitory effect on c-Jun N-terminal kinase (JNK)
Data(s) |
2014
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Resumo |
N-Alkyl substituted pyrazoloanthrone derivatives were synthesized, characterized and tested for their in vitro inhibitory activity over c-Jun N-terminal kinase (JNK). Among the tested molecules, a few derivatives showed significant inhibitory activity against JNK with minimal off-target effect on other mitogen-activated protein kinase (MAP kinase) family members such as MEK1/2 and MKK3,6. These results suggested that N-alkyl (propyl and butyl) bearing pyrazoloanthrone scaffolds provide promising therapeutic inhibitors for JNK in regulating inflammation associated disorders. |
Formato |
application/pdf |
Identificador |
http://eprints.iisc.ernet.in/49476/1/Org_Bio_Mol_Che_12-26_4656_2014.pdf Prasad, Karothu Durga and Trinath, Jamma and Biswas, Ansuman and Sekar, Kanagaraj and Balaji, Kithiganahalli N and Row, Tayur Guru N (2014) Alkyl chain substituted 1,9-pyrazoloanthrones exhibit prominent inhibitory effect on c-Jun N-terminal kinase (JNK). In: ORGANIC & BIOMOLECULAR CHEMISTRY, 12 (26). pp. 4656-4662. |
Publicador |
ROYAL SOC CHEMISTRY |
Relação |
http://dx.doi.org/10.1039/c4ob00548a http://eprints.iisc.ernet.in/49476/ |
Palavras-Chave | #Microbiology & Cell Biology #Solid State & Structural Chemistry Unit #Supercomputer Education & Research Centre #Physics |
Tipo |
Journal Article PeerReviewed |